Polynucleotides And Rosacea: Everything You Need To Know

I like to keep my ear to the ground when it comes to skin treatments so that I can identify and share any with you that I think will be of interest. I’ve been hearing about Polynucleotide treatments for a while now, and have received a few questions from readers who wondered if it would be an appropriate or useful treatment for rosacea.

So, of course, I asked my guru the incomparable Dr Anjali Mahto who has offered so much of her knowledge on my blog and social media over the years. You can find some of her previous contributions here: everything you could ever need to know about the skin barrier, all of your questions about laser for rosacea answered, tips about C-19 face masks and rosacea, and this fantastic Q&A on instagram.

All quotes below kindly provided by Dr Anjali Mahto, Consultant Dermatologist and Founder of Self London.

What are Polynucleotides?

Polynucleotides are chains of nucleotides, which are the basic building blocks of DNA and RNA. In dermatology, we use polynucleotides in cosmetic and regenerative treatments for skin repair and rejuvenation. They’re an injectable treatment that work by promoting tissue regeneration, improving hydration and stimulating collagen production. This makes them beneficial in reducing fine lines, improving skin elasticity, and enhancing overall skin health. It’s worth noting that under the right dermatological guidance, they can be an effective options for scar management too.

(I have to ask…) is it true that it’s salmon sperm?

Polynucleotides are derived from salmon DNA which is taken from salmon sperm. It’s used because it is highly biocompatible with human tissue, meaning it is well-tolerated and unlikely to cause adverse reactions in patients. The DNA extracted from salmon sperm undergoes an extensive purification and refinement process before being used in clinic.

How do Polyneucleotides work?

Polynucleotides work by activating the skin’s natural repair and regenerative processes. When introduced into the skin, they stimulate fibroblasts, the cells responsible for producing collagen, which helps repair damaged tissue and improves skin elasticity. They also have anti-inflammatory properties, which help reduce inflammation and promote healing, making them beneficial for treating wounds and scars (under the right guidance). Polynucleotides also improve skin hydration by binding to water molecules, boosting moisture levels and reducing the appearance of fine lines. They’re a great all-rounder and it’s fast becoming one of the more popular treatments in the clinic.

Are Polynucleotides just for the undereyes?

No, polynucleotides are not limited to the under-eye area. While they are often used to treat concerns like dark circles, fine lines, and thinning skin under the eyes, they can also be applied to other areas of the face and body. These treatments are effective for facial rejuvenation, improving skin texture, and reducing wrinkles and sagging in areas such as the cheeks, neck, and décolletage. Additionally, polynucleotides are used for wound healing, scar reduction, and improving skin hydration and elasticity in various parts of the body. Their versatility makes them suitable for addressing a wide range of skin concerns, not just the under-eye area, but a thorough consultation with a Consultant Dermatologist is advised first to ensure it’s the right treatment for your individual concerns.

What is the process for having a Polynucleotide treatment?

First, a consultation is done to assess the patient’s skin and determine the appropriate treatment areas – we would never treat on the same day as the consultation as we want the patient to go away and think about the information we’ve presented to them.

If you decide to go ahead, you’ll come into the clinic and your skin will be cleaned and a topical numbing cream may be applied to minimise discomfort. Once the skin is prepared, the polynucleotides are injected into the targeted areas using very fine needles or a cannula. These injections are typically placed just below the skin’s surface to promote collagen production, hydration and tissue repair.

Do Polynucleotide treatments hurt?

Polynucleotide treatments are generally well-tolerated and discomfort is usually minimal. As mentioned, a topical numbing cream is typically applied to the treated area beforehand to reduce any potential pain during the injections. Most patients report feeling only mild pressure or a slight pinching sensation during the procedure.

What is the downtime?

After the treatment, there may be mild swelling or redness, which usually subsides within a few hours to days. Recovery is quick, with most patients able to resume normal activities immediately.

What are the results?

Results, such as improved skin texture and elasticity, usually become visible over the next few weeks as the polynucleotides stimulate the skin’s regenerative processes. The results of polynucleotide treatments are not immediate. While some patients may notice subtle improvements in skin hydration and texture shortly after the procedure, the more significant effects, such as increased firmness, elasticity and reduction of fine lines, typically become visible over the course of a few weeks. This delay is due to the time required for the polynucleotides to stimulate collagen production and promote skin regeneration.

How long do the results last?

The results of polynucleotide treatments can last between six months to a year, depending on various factors such as individual skin type, age, lifestyle, and the specific area treated. Many patients find that maintaining a regular treatment schedule (typically one or two sessions per year) helps to prolong the effects.

How does it compare to Profhilo?

Polynucleotides and Profhilo are both injectable treatments used for skin rejuvenation, but they have different purposes. Polynucleotides focus on promoting tissue regeneration, collagen synthesis, and hydration. They are effective for repairing damaged skin, improving elasticity, and reducing fine lines.

Profhilo, on the other hand, is a form of hyaluronic acid that is highly concentrated. It provides intense hydration and bio remodeling effects, helping to improve skin texture and firmness.

How does it compare to traditional filler?

In short, they don’t. Polynucleotides and traditional fillers serve different purposes in aesthetic treatments. Traditional fillers, typically made of hyaluronic acid or other substances, are used to add volume and plump specific areas of the face, such as cheeks, lips, and nasolabial folds. They provide immediate results by filling in lines and restoring lost volume, but their effects usually last six months to a year.

Who would benefit from Polynucleotides?

Polynucleotides can benefit a variety of individuals, particularly those experiencing signs of ageing, such as fine lines and sagging skin. They are also effective for reducing post-acne scarring and improving overall skin hydration and texture. Younger adults seeking preventive care and enhanced skin quality may find these treatments helpful as well. Additionally, those preparing for or recovering from cosmetic procedures can use polynucleotides to promote healing and enhance results.

Is it unsuitable for anyone?

Anyone with active infections or skin conditions in the treatment area, such as eczema, cold sores or dermatitis wouldn’t be suitable for treatment. Patients with a history of severe allergies or hypersensitivity to any components of the product should also avoid these treatments. Pregnant or breastfeeding individuals are generally advised to wait until after this period. Additionally, those with certain medical conditions or taking medications that affect healing should consult their healthcare provider before undergoing treatment. This is why a thorough consultation with a dermatologist beforehand is vital so we can help identify any potential contraindications.

Are Polynucleotides suitable for rosacea/sensitive skin?

Polynucleotides can be suitable for individuals with rosacea or sensitive skin, as they have anti-inflammatory properties that may help soothe and repair the skin. However, it’s crucial to approach treatment with caution. A thorough consultation with a dermatologist is essential to assess the specific condition of the skin and determine the best course of action. They can evaluate the severity of rosacea or sensitivity and decide if polynucleotide treatment is appropriate or if alternative options should be considered.

What benefits could this treatment offer for rosacea?

In theory, polynucleotide treatment can offer several benefits for individuals with rosacea, but at present there are no robust clinical trials as it’s a relatively new treatment and more data is needed before we can confidently say it can be of benefit. Therefore, in theory, their anti-inflammatory properties may help reduce redness and swelling associated with the condition. By promoting tissue repair and enhancing skin hydration, polynucleotides can improve overall skin texture and resilience, making it less reactive. Additionally, they may aid in calming irritation and supporting the skin’s natural barrier function, which is often compromised in rosacea patients.

What training does a person need to provide this treatment?

Unfortunately, like a lot of the aesthetic industry, it’s unregulated meaning that anyone can inject. My advice would be to look for someone who is competent in facial anatomy, physiology and someone who is competent carrying out procedural treatments e.g. Dermatologists, GPs and Plastic Surgeons.

What questions should I ask a provider before the treatment?

The first thing I would do is ensure you’re seeing a Consultant Dermatologist. You can do this by checking if they’re on the specialist register on the GMC website. Beyond this, here are some of the questions I’d suggest you ask:

  • What qualifications and experience do you have with polynucleotide treatments?
  • Are you a CQC registered clinic?
  • What specific benefits can I expect based on my skin type and concerns?
  • What does the procedure involve, and how long does it take?
  • Are there any potential side effects or risks I should be aware of?
  • How many sessions will I need to achieve optimal results?
  • What is the expected downtime, and when can I resume normal activities?
  • How long do the results typically last, and what maintenance is recommended?
  • Are there any contraindications or conditions that would make this treatment unsuitable for me?

A huge thank you to Dr Anjali Mahto for her time and expertise, it’s so appreciated. You can find more information about her beautiful London clinic HERE, and if you want to follow her on instagram, you can find her own page HERE and and Self’s instagram page HERE.

Lex

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